A multitude of issues have dragged him down by the sounds of it.
Got to get on with living. A rolling stone gathers no moss. Big things, both good and bad will happen. Have to regognise, remember and release. A good life is all about enjoying all the little things. A day with a friend, a hit of golf of a summer evening. Fishing. Walking the dog..
Also have to eliminate the bad triggers eg alcohol or negative friends.
Easy for me to say as i have only ever been down at times, before getting myself up quickly. Francis might have a chemical imbalance.