A few of my favourites...
Lord of the Rings
Gandalf:
"Is it secret? Is it safe?"
"Fly you fools"
Apollo 13
Jim Lovell: "Houston, we have a problem."
Star Wars
Obi-Wan Kenobi: "Use the force Luke"
Dirty Harry
Harry Callahan: "Ah Ah, I know what you're thinking, punk. You're thinkin', 'Did he fire six shots or only five?' Now, to tell you the truth, I've forgot myself in all this excitement. But being as this is the .44 Magnum, the most powerful handgun in the world, and will blow your head clean off, you've got to ask yourself a question: 'Do I feel lucky?' Well, do ya, punk?"
Austin Powers: International Man of Mystery
Dr. Evil:
"Why must I be surrounded by frickin' idiots?"
"Can you remind me what I pay you people for? Honestly, throw me a bone here!"
Austin Powers: The Spy Who Shagged Me
Dr. Evil:
"The moon unit will be divided into two divisions: Moon Unit Alpha and Moon Unit Zappa."
"You're not quite evil enough. You're semi-evil. You're quasi-evil. You're the margarine of evil. You're the Diet Coke of evil, just one calorie, not evil enough."
"Why make trillions when we could make... billions?"
" I turned the moon into something I like to call a 'Death Star.' "
"[deep voice] Austin, I'm your father"
Austin: "Really?"
"No, I can't back that up."
As Good As It Gets
Melvin: "Sell crazy some place else... we're all stocked up here."