News Coronavirus Thread

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Snake_Baker

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han five years. An Australian research team hopes to do it in five weeks.


Australian scientists are fast-tracking the development of a COVID-19 blood test to help predict which patients will need an intensive care bed and who will have only mild symptoms.


The triaging tool could be crucial for frontline doctors trying to determine whether their patients will deteriorate within 24 hours or can be sent home to self-isolate, freeing up finite medical resources, as hospitals prepare for a potential deluge of cases.


The test that detects a biomarker used to identify high risk flu patients has several hurdles to clear before it’s proven effective for COVID-19. A crowdfunding campaign to support the work comes as researchers across the globe rush out promising but unproven diagnostics and treatments.


Lead researcher Associate Professor Benjamin Tang said he was cautiously hopeful their test would be proven effective for coronavirus because it built on a decade of investigating biomarkers in preparation for such a pandemic.


Developing such a test would usually take more than five years. The research team hopes to do it in five weeks, said the researchers from the University of Sydney’s Marie Bashir Institute for Infectious Diseases and Biosecurity, Westmead Institute for Medical Research and Nepean Hospital.


The test looks for a single-gene biomarker IFI27 - used as an early warning sign for patients at high risk of influenza. The High-risk Influenza Screening Test (HIST) was developed by Dr Tang after he saw footage of the 2009 swine flu pandemic of overwhelmed emergency departments clogged with patients.


The IFI27 gene is released into a patient’s bloodstream, mobilising their immune system against the virus.


“When our body is being attacked by the virus, the immune system gets switched on. When it gets switched on, it starts telling all the other immune cells to come and fight the virus. During that process, the immune system gives out a lot of dangerous signals," Professor Tang said.


“That is what we're measuring through this blood test."
Interesting.

A lot of the data appears to be pointing towards initial viral loading upon the commencement infection with regard to correlations with symptomology and co-morbidity factors afterward.

Infection at a cellular level occurs at ~10 minutes, the replication process then occurs in ~10 hours, which results in ~1000 replicated viruses being released in to the body to infect more cells, and from this point onward the race is on between the virus and the immune system in order to see which is going to win the battle for replication and/or destruction, in accord with the antibody response which can typically take between 10 to 20 days.

Now, when you factor an initial viral load for example, a few particles or 500 or more particles in to the equation, you can see how this impacts upon the start of the race. Then you factor in immune lag correlated to age, and other comorbidity and you can get the general picture.

Basic nasal/sputum sampling can give good readings with regard to viral loading.
 

Snake_Baker

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Not a single piece of proof provided to back up his assertions either.
Professor alt account strikes again.

Keep punching out the inane stuff for the masses, and move along.

Anyway, podcast from Nabs chief economist talking through some of what we may be looking at.

Through the eyes of the NAB.
 

gokangas

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This is being managed better than in any other comparable country.
Not questioning the outcomes. The comms have been pathetic - confusing, contradictory and rambling. Very poor. Make a statement in the morning, clarify in the afternoon, correct the next morning over and over again. The Vic State Gov is one of the largest employers of PR and Comms folk in the country and they continue to blunder their way through the comms. It's laughable.
 

roos_fanatic08

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Interesting.

A lot of the data appears to be pointing towards initial viral loading upon the commencement infection with regard to correlations with symptomology and co-morbidity factors afterward.

Infection at a cellular level occurs at ~10 minutes, the replication process then occurs in ~10 hours, which results in ~1000 replicated viruses being released in to the body to infect more cells, and from this point onward the race is on between the virus and the immune system in order to see which is going to win the battle for replication and/or destruction, in accord with the antibody response which can typically take between 10 to 20 days.

Now, when you factor an initial viral load for example, a few particles or 500 or more particles in to the equation, you can see how this impacts upon the start of the race. Then you factor in immune lag correlated to age, and other comorbidity and you can get the general picture.

Basic nasal/sputum sampling can give good readings with regard to viral loading.
I read a article about this very early in the piece.

It mentioned that (obviously) front line medical workers and infected cruise ships would be the highest risk in term of high amounts of viral load. The cruise ship statement is turning out to be true considering the number of people dying where they were originally infected there.

Seems that the Viral load has had a big impact in Italy too. Large families living together in close confines would most likely result in high viral load and thus death as well.
 

Sopwiths North

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Don't hide amongst the semantics, where's your data to support your bullshit link?

"They had a cough one minute, we gave them seaweed, horse semen & echinacea, and a week later they didn't have a cough any longer", will not suffice.
Okay, well that's good because:

Echinacea is a North American plant, and so no, not part of TCM

Seaweed is widely used in Asian cuisine, and no, is not used in TCM

Horse semen is, well, horse semen, and not a plant, and no, not used in TCM.

So phew, we're okay there!

As for more data, okay sure. To add to the two links I've already provided you with, which list in extensive detail the acupuncture points and Chinese herb protocols prescribed for and administered to patients in Wuhan by symptom, as well as by disease stage, here is a study compiled by one of the TCM doctors on 30 Covid19 patients she treated from start to finish with Traditional Chinese Medicine during the Wuhan outbreak. She provides detailed cases if you scroll down a little, including symptoms and CT images. All 30 patients recovered fully and were discharged.

https://www.elotus.org/article/medi...nal-chinese-medicine-tcm-doctor-fighting-covi
 

Soft Downhill Skier

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Not questioning the outcomes. The comms have been pathetic - confusing, contradictory and rambling. Very poor. Make a statement in the morning, clarify in the afternoon, correct the next morning over and over again. The Vic State Gov is one of the largest employers of PR and Comms folk in the country and they continue to blunder their way through the comms. It's laughable.
No, the communication in a situation this unprecedented has been clear.
 

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DesertRoo

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Pretty impressive given the short period of time.




Not sure I would want to beta test a Tesla ventilator though...

How about having one from the guys from triple 8 Supercars.
Honestly having a natural aspirating one would be boring at this point.

 

Steamin Beamin

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Still sound a bit anecdotal to me, one TCM doctor's patient history just isnt quite enough to prove that it works.
It's actually similar to some of these drug re-purposing trial results I've read; they say the patient had drastic improvement, but they also pick and choose samples which is quite unethical.
 

Tas

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I read a article about this very early in the piece.

It mentioned that (obviously) front line medical workers and infected cruise ships would be the highest risk in term of high amounts of viral load. The cruise ship statement is turning out to be true considering the number of people dying where they were originally infected there.

Seems that the Viral load has had a big impact in Italy too. Large families living together in close confines would most likely result in high viral load and thus death as well.
I think it is probably due to the long incubation period before the body starts to fight it, read something on the virus that each infected cell can release millions of copies of the virus before the cell breaks down and dies, can imagine being hit with a massive amount of the virus your body would just be overwhelmed by how much of the virus has replicated in your body.
 

Sopwiths North

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Show me mechanism of action, and equimolar efficacy that supports the symbiotic application of:

15g Huang Qi
10g fried Bai Zhu
10g Fang Feng
10g Mian Ma Guan Zhong
10g Jin Yin Hua
6g Chen Pi
10g Pei Lan

.....in order to mitigate pneumonia. How does this mitigate macrophage Interleukin-6 acute response and neutrophil chemotaxis?


Then explain the same factors for how this concoction addresses the potentially deadly scenario of a temperature above 37.8C:

30g Ma Huang
15g Ku Xing Ren
15g Zhi Gan Cao
20-50g Shi Gao ??????????????
15g Gui Zhi
3 slices Sheng Jiang ?????????????
10 pieces Da Zao (cut it open) ??????????????


Provide a complete set of blood diagnostics and chest scans with your responses.
Nah, that's not how TCM works. It's a whole different way of looking at the body systems. Not even remotely like Western Medicine. Blood work would be pretty much meaningless in TCM, although the doctors did look at the CT scans, if you have a read through the studies. TCM is based on an entirely different way of assessing a patient's health status. And while it's clear that both modalities can work together, the two approaches will never be like synchronised swimming. It's more like taking two separate routes to reach the same destination. The maps are different.
 

ferball

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The thing is we didn't need to go to war to topple Hussein, they just should have put a ban on supplying weapons to them, Iran/Shia majority would have done the rest, dictators can only rule by force. Most of the regimes in the middle-east rule largely because they are propped up by either USA or Russia.
They should have just finished what they were doing in Afghanistan first.

Why start two jobs and fu** em both up when you can do one properly.
 

7577969919

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Nah, that's not how TCM works. It's a whole different way of looking at the body systems. Not even remotely like Western Medicine. Blood work would be pretty much meaningless in TCM, although the doctors did look at the CT scans, if you have a read through the studies. TCM is based on an entirely different way of assessing a patient's health status. And while it's clear that both modalities can work together, the two approaches will never be like synchronised swimming. It's more like taking two separate routes to reach the same destination. The maps are different.
If you can't prove it scientifically then I'll stick with my leeches and bloodletting.

Can you show just one peer-reviewed scientific study that supports the efficacy of TCM at any level above placebo?
 

ferball

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It's interesting watching the SJW's high fiving and slapping each others butts over Boris Johnson's predicament, in the knowledge that these very same people completely lose their minds if anyone's dare to challenge the integrity of Greta Thunberg's climate stance.

Petty vicious little hypocrites.

Q: What is the difference between a Nazi and an SJW?
A: The Nazi is sincere.
I don't want to see anyone else die of this thing, even a campaigner like Johnson.
 

Kangaroos4eva

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Neo Liberal capitalist countries appear to want it both ways. Nobody forced the world to take advantage of China's cheap wages and products for the last couple of decades. It's a decision made in countries like ours because people with lots of money here want to make more money here and even more money there. At some point there has to be some responsibility taken - we chose to dance and now when it turns sour we want to paint them as the devil. It's a choice made out of pure greed. China didn't change overnight - it just caught up with us.



They don't want to lose power - I doubt human rights abuses are a high priority worry, same as they aren't for western nations that use the sword as it suits them while pontificating from high.

What is true is that they are not going to willingly sign up to their own loss of power. The reality is that the simplest way to reduce China's power as a nation is to reduce trading with them - a decision that most western nations refuse to make because lots of people, with lots of money make good profits out of the current status quo.



Not convinced there really is much of a feud. Much like Sino-Japanese relations pointing the finger at an old enemy rates well internally - it's a nice distraction for the masses but I doubt there's genuine interest in these feud's at a high level outside of the power they leverage for politicians and leaders.
There's a whole heap of reasons, I just stated one of them. Power is the obvious one, which is more centralised amongst the communist elite in China. They are just as concerned about internal strife resulting in a loss of power, as they are about international concerns.

I would argue that the USA's dedication of a major military strategy in the form of the AirSeaBattle strategy and a recent trade war would both indicate a feud of sorts. Of course, wars (whether it be trade or a military conflict) are the sum of decisions, actions, and reactions in an uncertain and dangerous context, and also as a socio-political phenomenon, often driven by domestic concerns.
 

Tas

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They should have just finished what they were doing in Afghanistan first.

Why start two jobs and fu** em both up when you can do one properly.
If the USA was balls into fracking during the Bush era then I don't think the war would have happened. USA is now a major exporter of crude oil thanks to fracking. At the time of the war, the USA was reliant on 70% of their oil from imports and there had been a major threat to their supply thanks to Iraq.
 

ferball

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People weren’t contagious till well after showing symptoms so it was easier to contain.

ferball After SARS COV-1 died out the funding just wasn’t there to find a vaccine. Though there were a few people that were pushing for funding but it fell on deaf ears. If they had of kept at it then we wouldn’t be in this situation.
I dunno about that. I there is at least one study where the addition of antibodies increases SARS efficiency at binding to the receptor site significantly. I think perhaps the reason that Harvard bloke was arrested is because there is Chineses funding for research on corona viruses, Chinese organisations do contribute to SARS finding, it's why I mentioned UNC earlier. Their Chapel Hill campus did some SARS research.

Maybe with more funding over that time they'd have had success but it is a difficult problem. However one good thing that seems to be coming from this situation is that lots of this research is being made available, open source and shared immediately. That may help.
 
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