Science/Environment Covid-19 Treatments

[Frank Bunn]

Covid-19 Treatments

 

[Kurve]

Success against COVID19 will likely require both vaccines & treatments.

What are the likely treatments that will be effective against Covid-19?

Doesn't look like it's ivermectin, it's a combination of others including Ritonovir which has been used to control HIV.

 

[Chief]

Fluvoxamine reported as promising:

How a cheap antidepressant emerged as a promising Covid-19 treatment

Most Covid-19 drug treatments that have been included in trials haven’t panned out. A large new study suggests fluvoxamine might be different.

www.vox.com

Hydroxychloroquine, enthusiastically endorsed by President Trump last year, has been shown to have no measurable benefits. New drugs like monoclonal antibodies — proteins meant to imitate the immune system’s response to the disease — have been approved by regulators but must be administered by a doctor through an IV or series of injections.

But scientists haven’t stopped searching, and the results of a new massive clinical trial suggest they’re getting somewhere. In a large, randomized clinical trial conducted with thousands of patients over the past six months, researchers at McMaster University tested eight different Covid-19 treatments against a control group to figure out what works.

One drug stood out: fluvoxamine, an antidepressant that the Food and Drug Administration has already found to be safe and that’s cheap to produce as a generic drug.

258: How to reason about COVID, and other hard things (Kelsey Piper) – Rationally Speaking Podcast

rationallyspeakingpodcast.org

 

[undefined]

Interim results from the Together trial show no benefit from Ivermectin as a prophylactic or treatment, much to the sadness of all the anti-vax idiots I know. The prices you pay for living in Queensland, eh.

 

[undefined]

Fluvoxamine reported as promising:

How a cheap antidepressant emerged as a promising Covid-19 treatment

Most Covid-19 drug treatments that have been included in trials haven’t panned out. A large new study suggests fluvoxamine might be different.

www.vox.com

Hydroxychloroquine, enthusiastically endorsed by President Trump last year, has been shown to have no measurable benefits. New drugs like monoclonal antibodies — proteins meant to imitate the immune system’s response to the disease — have been approved by regulators but must be administered by a doctor through an IV or series of injections.

But scientists haven’t stopped searching, and the results of a new massive clinical trial suggest they’re getting somewhere. In a large, randomized clinical trial conducted with thousands of patients over the past six months, researchers at McMaster University tested eight different Covid-19 treatments against a control group to figure out what works.

One drug stood out: fluvoxamine, an antidepressant that the Food and Drug Administration has already found to be safe and that’s cheap to produce as a generic drug.

258: How to reason about COVID, and other hard things (Kelsey Piper) – Rationally Speaking Podcast

rationallyspeakingpodcast.org

It baffles my (admittedly non-scientific) mind that an SSRI could treat any virus, let alone Covid.

 

[Chief]

It baffles my (admittedly non-scientific) mind that an SSRI could treat any virus, let alone Covid.

I know, right?

It's showing real promise, but it still has to go through the full review process, so it could amount to nothing.

 

[Jibroni]

Interim results from the Together trial show no benefit from Ivermectin as a prophylactic or treatment, much to the sadness of all the anti-vax idiots I know. The prices you pay for living in Queensland, eh.

Not so sure about that (Ivermectin), our government simply seems incompetent to understand its benefit as explained in this video.

 

[Chief]

a World Health Organisation clinical trial

Any other evidence?

 

[Chief]

Not so sure about that (Ivermectin)

There is no coherent evidence for the use of ivermectin.

 

[kickazz]

Not so sure about that (Ivermectin), our government simply seems incompetent to understand its benefit as explained in this video.

He doesn't mention anything about any supposed efficacy. He is criticising the rationale of the government's approach (i.e. people won't listen to their doctors, they'll only follow social media, so let's ban doctors from prescribing because we don't trust people will listen to and follow their prescription anyway), not the government's understanding of Ivermectin.

 

[HurleyHepsHird]

Success against COVID19 will likely require both vaccines & treatments.

What are the likely treatments that will be effective against Covid-19?

We have to be very careful to be judicious with the use of novel anti-virals.

Previous as hens teeth.

 

[HurleyHepsHird]

Fluvoxamine reported as promising:

How a cheap antidepressant emerged as a promising Covid-19 treatment

Most Covid-19 drug treatments that have been included in trials haven’t panned out. A large new study suggests fluvoxamine might be different.

www.vox.com

Hydroxychloroquine, enthusiastically endorsed by President Trump last year, has been shown to have no measurable benefits. New drugs like monoclonal antibodies — proteins meant to imitate the immune system’s response to the disease — have been approved by regulators but must be administered by a doctor through an IV or series of injections.

But scientists haven’t stopped searching, and the results of a new massive clinical trial suggest they’re getting somewhere. In a large, randomized clinical trial conducted with thousands of patients over the past six months, researchers at McMaster University tested eight different Covid-19 treatments against a control group to figure out what works.

One drug stood out: fluvoxamine, an antidepressant that the Food and Drug Administration has already found to be safe and that’s cheap to produce as a generic drug.

258: How to reason about COVID, and other hard things (Kelsey Piper) – Rationally Speaking Podcast

rationallyspeakingpodcast.org

Yeah, a small group of SSRIs have the same utility/similar mechanism for combatting COVID symptoms as two corticosteroids, which is interrupting inflammatory pathways.

For the same reason Fluoxetine shows promise in tackling conditions that may lead to cognitive decline, it also may help limit pro-inflammatory cascades (cytokine storms) in other parts if the body.

Whilst this targeted at impeding some feature of the virus, like replication, but instead symptoms management, it still holds promise if it reduces COVID mortality. Much like paracetamol and viral induced fever.

 

[Pie eyed]

Interim results from the Together trial show no benefit from Ivermectin as a prophylactic or treatment, much to the sadness of all the anti-vax idiots I know. The prices you pay for living in Queensland, eh.

Makes me laugh quite a bit that an anti vaxxer would rather have a cattle delouser than an actual vaccine.
Same type idiots who want the right to let their kids bleed out rather than have blood transfusions.

 

[Chief]

let's ban doctors from prescribing

GP’s anyway. Specialists can still prescribe it.

 

[Brad Goodman]

Whatever saved Trump must have worked well. Someone of his age and dimensions would’ve been pretty high risk.

 

[undefined]

Whatever saved Trump must have worked well. Someone of his age and dimensions would’ve been pretty high risk.

Was it not monoclonal antibodies? That JR had?

 

[Chief]

Whatever saved Trump must have worked well. Someone of his age and dimensions would’ve been pretty high risk.

At the time they said it was hundreds of thousands of dollars worth of treatment.

That the care they gave him was the type of care they throw at someone who is on death’s door, not just in the front door with fresh symptoms.

 

[yodellinhank]

Thymosin. The good one, obviously.

 

[owen87]

Thymosin. The good one, obviously.

Dank was really ahead of his time. Replace Sutton ASAP.

 

[Chief]

The TGA did not say anything about efficacy either.

Because it's a given.

And your version of the TGA statement doesn't match the TGA statement:

The three reasons they cited for prohibiting GPs prescribing Ivermectin are :

i) people may not choose to get vaccinated or tested
ii) social media might lead to people taking incorrect dosages
iii) people using Ivermectin for Covid might lead to shortages for those who need it for scabies and parasite infections

Firstly, - Individuals who believe that they are protected from infection by taking ivermectin may choose not to get tested or to seek medical care if they experience symptoms.

(Note: It's a good chance it's happening already.)

Secondly, the doses of ivermectin that are being advocated for use in unreliable social media posts and other sources for COVID-19 are significantly higher than those approved and found safe for scabies or parasite treatment. These higher doses can be associated with serious adverse effects, including severe nausea, vomiting, dizziness, neurological effects such as dizziness, seizures and coma.

(Note: No "might" at all)

Finally, there has been a 3-4-fold increased dispensing of ivermectin prescriptions in recent months leading to national and local shortages for those who need the medicine for scabies and parasite infections.

(Note: No "might" - shortages are happening.)

 

[Chief]

This is the full TGA statement for 'New restrictions on prescribing ivermectin for COVID-19'.

Yes - I linked it earlier and quoted it.

You are trying to make it sound like they are speculating. They are not. They are responding to things that are happening.

 

[Chief]

On 9 August 2021 the Therapeutic Goods Administration (TGA) granted provisional determination to Merck Sharp & Dohme (Australia) Pty Ltd (MSD) in relation to Molnupiravir.​

​

This oral antiviral monotherapy will be considered for treatment of COVID-19 in adults.​

​

Molnupiravir is considered to have broad-spectrum activity against a range of RNA viruses including SARS-CoV-2, which causes COVID-19. Molnupiravir works by inhibiting replication of SARS-CoV-2.​

​

The granting of a provisional determination means that the TGA has made a decision that MSD is now eligible to apply for provisional registration for Molnupiravir in the Australian Register of Therapeutic Goods (ARTG). Provisional determination is the first step in the process. It is anticipated that MSD will submit an application for provisional registration shortly.​

Based on FDA's purchase commitment in the US, the treatment would cost about $AUD 950 per patient.

Cheap if it saves your life.

 

[owen87]

a repurposed drug like Fluvoxamine

* if it works

 

[owen87]

Pfizermectin is a step closer.

I mean. Ivermectin is an anti-parasitic.

So aside from your idiotic play on words, what relevance does it have?

 

[SaintsSeptember]

Because it's a given.

And your version of the TGA statement doesn't match the TGA statement:



Firstly, - Individuals who believe that they are protected from infection by taking ivermectin may choose not to get tested or to seek medical care if they experience symptoms.

(Note: It's a good chance it's happening already.)

Secondly, the doses of ivermectin that are being advocated for use in unreliable social media posts and other sources for COVID-19 are significantly higher than those approved and found safe for scabies or parasite treatment. These higher doses can be associated with serious adverse effects, including severe nausea, vomiting, dizziness, neurological effects such as dizziness, seizures and coma.

(Note: No "might" at all)

Finally, there has been a 3-4-fold increased dispensing of ivermectin prescriptions in recent months leading to national and local shortages for those who need the medicine for scabies and parasite infections.

(Note: No "might" - shortages are happening.)

I just hope the shortages aren't affecting the supply to Africa.
It would be pretty shitty if some kids went blind because someone had used their annual treatment instead of the good snakeoil.