Science/Environment Covid-19 Treatments

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Mofra

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Do the quote marks imply that you don't think Big Pharma is a thing?

It seems to me that it's a multi billion dollar industry that spends more on political lobbying and PR than research. It maximises profits by exaggerating the risk of certain health threats, downplays the addictive qualities and other adverse effects of its products, and gaslights other treatments - at the total disregard of the health of the population.
There are certainly problems with some large pharmaceutical companies, and I've actually studied some of the large US players in their dealings primarily in patent farming and "me too" drugs.
That's even before you consider the single-chain supply contracts that are killing the US health system.

The problem is every tin-foil hat wearing nutjob with internet access ignores all of these issues and focusses on vaccines. Vaccine manufacturing isn't the issue.
Arguably, it's the least corrupted sector of the global pharmaceutical industry.
 

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Fluvoxamine?

Nothing seems to work unless the drugs companies can make billions out of it.
That might stop your obsession with off-label drug treatments.

There are plenty of drug manufacturers who manufacture "generic" medicine. When there is no patent anyone can make it.
If a cheap drug was deemed effective , someone would supply it.

The big companies seem to have method in their research though.
Others seem to think the best way to find a cure is to rummage through the medicine cabinet and try all the different stuff and see if it works.
"Hmmmm this Vicks Vapo rub seems promising when taken anally".
 

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That might stop your obsession with off-label drug treatments.
I've got an obsession with drugs that work and a huge suspicion of Big Pharma practices to maximise their profits without any regard to health consequences.

There are plenty of drug manufacturers who manufacture "generic" medicine. When there is no patent anyone can make it.
If a cheap drug was deemed effective , someone would supply it.
We are talking about cheap drugs that have a longstanding safety record, so at worst they don't do any harm but at best could save many lives. They are gaslighted, not funded for trials, and even prohibited for use.

Whereas the Big Pharma treatments get funded for trials, are approved with no long term safety record and are very expensive.
 

SaintsSeptember

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I've got an obsession with drugs that work and a huge suspicion of Big Pharma practices to maximise their profits without any regard to health consequences.



We are talking about cheap drugs that have a longstanding safety record, so at worst they don't do any harm but at best could save many lives. They are gaslighted, not funded for trials, and even prohibited for use.

Whereas the Big Pharma treatments get funded for trials, are approved with no long term safety record and are very expensive.
It is very evident that a single dose of Ivermectin per year will not be effective against Covid.
Ivermectin works as a nerve toxin against parasites. What could possibly go wrong with continual/much higher doses?

Like i said, if "Little Pharma" ( generic drug makers ) saw a market in it, they'd be going gung ho.

The reasons they have prohibited the drugs for use are stated and valid.
 

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It is very evident that a single dose of Ivermectin per year will not be effective against Covid.
Ivermectin works as a nerve toxin against parasites. What could possibly go wrong with continual/much higher doses?
0·2 mg/kg for 3 or 5 days seems to be the going rate. From a study in Israel. Patients assigned to the intervention arm received ivermectin in a dosage regimen according to body weight; patients 88 weighing between 40-69 kg received four tablets (=12mg) daily and patients weighing ≥70kg received five tablets 89 (=15mg) daily, all for three days.

It doesn't work as a nerve agent. It acts as an anti-inflammatory to lung function and for mechanisms that block the virus at different stages.
 

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0·2 mg/kg for 3 or 5 days seems to be the going rate. From a study in Israel. Patients assigned to the intervention arm received ivermectin in a dosage regimen according to body weight; patients 88 weighing between 40-69 kg received four tablets (=12mg) daily and patients weighing ≥70kg received five tablets 89 (=15mg) daily, all for three days.

It doesn't work as a nerve agent. It acts as an anti-inflammatory to lung function and for mechanisms that block the virus at different stages.
Oh good , there is a "going rate"
You say that it is well proven , but the anti-inflammatory properties for blocking the virus are NOT well proven. Its use at high doses cannot be ruled safe.


We have a drug that was investigated because it killed Covid in the laboratory.
That didn't work in the human body, so now we want to use it because it "might" have anti-inflammatory properties.

It is a proven nerve agent, killing parasites , but it doesn't readily cross the blood brain barrier.
Do i want to have it constantly in my system?
 

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Oh good , there is a "going rate"
You say that it is well proven , but the anti-inflammatory properties for blocking the virus are NOT well proven. Its use at high doses cannot be ruled safe.
We've been round this loop before.

From the PRINCIPLE study website. It gives evidence for safe dosages of Ivermectin for its trial. And cites that 2.7 billion treatments of oral ivermectin have been given with minimal safety concerns.

An oral dose of 300 ug/kg body weight for 3 days will be used in this trial. This was shown to be safe in a recent study in Kenya as part of combination treatment for malaria. Higher doses of 400 µg/kg for 5 days have been used in studies of COVID-19.​

https://secure.phc.ox.ac.uk/sentry/national111/live/survey/pisv9
 

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It was 23 June 2021 that PRINCIPLE announced their study into Ivermectin

a safe, broad spectrum antiparasitic drug which is in wide use globally to treat parasitic infections.​
With known antiviral properties, ivermectin has been shown to reduce SARS-CoV-2 replication in laboratory studies. Small pilot studies show that early administration with ivermectin can reduce viral load and the duration of symptoms in some patients with mild COVID-19. Even though ivermectin is used routinely in some countries to treat COVID-19, there is little evidence from large-scale randomised controlled trials to demonstrate that it can speed up recovery from the illness or reduce hospital admission.​

Despite this being a health emergency, several months later - crickets.

From July 8, 2021 the US National Institutes of Health said

There is insufficient evidence for the Panel to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.​

Despite this being a health emergency, several months later - crickets.
 

SaintsSeptember

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It was 23 June 2021 that PRINCIPLE announced their study into Ivermectin

a safe, broad spectrum antiparasitic drug which is in wide use globally to treat parasitic infections.​
With known antiviral properties, ivermectin has been shown to reduce SARS-CoV-2 replication in laboratory studies. Small pilot studies show that early administration with ivermectin can reduce viral load and the duration of symptoms in some patients with mild COVID-19. Even though ivermectin is used routinely in some countries to treat COVID-19, there is little evidence from large-scale randomised controlled trials to demonstrate that it can speed up recovery from the illness or reduce hospital admission.​

Despite this being a health emergency, several months later - crickets.

From July 8, 2021 the US National Institutes of Health said

There is insufficient evidence for the Panel to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.​

Despite this being a health emergency, several months later - crickets.
Its use as against malaria was as a nerve agent, If Mosquito's fed on a host with Ivermectin, it killed the Mosquito. It was deemed impractical because entire communities needed to be dosed with Ivermectin on a continual basis.
If it has anti-inflammatory properties that can treat Covid, then that's a co-incidence.
Might as well try every other known drug , just in case it has a good effect against Covid.
 

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Its use as against malaria was as a nerve agent, If Mosquito's fed on a host with Ivermectin, it killed the Mosquito. It was deemed impractical because entire communities needed to be dosed with Ivermectin on a continual basis.
If it has anti-inflammatory properties that can treat Covid, then that's a co-incidence.
Might as well try every other known drug , just in case it has a good effect against Covid.
That makes no sense. The Oxford University Principle trial and the US National Institute of Health have both said Ivermectin needs to be studied further for its potential to speed up recovery from illness and reduce hospital admission. But many months later in this emergency situation they have done nothing.
 

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That makes no sense. The Oxford University Principle trial and the US National Institute of Health have both said Ivermectin needs to be studied further for its potential to speed up recovery from illness and reduce hospital admission. But many months later in this emergency situation they have done nothing.
That makes no sense. If it is funding they need why haven't the billionaires who have had our best interest at heart like Trump and Palmer stepped in and stumped in some cash.
 

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That makes no sense. The Oxford University Principle trial and the US National Institute of Health have both said Ivermectin needs to be studied further for its potential to speed up recovery from illness and reduce hospital admission. But many months later in this emergency situation they have done nothing.
The more they find out about the studies the less inclined they are to look to Ivermectin as a cure.
 

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The more they find out about the studies the less inclined they are to look to Ivermectin as a cure.
The article cites an unreliable study being retracted then admitting their study was unreliable.

It's a non sequitur to my point that the Oxford University Principle trial and the US National Institute of Health have both said Ivermectin needs to be studied further for its potential to speed up recovery from illness and reduce hospital admission. But many months later in this emergency situation they have done nothing.

Meanwhile in the real world, take a guess at when Indonesia started handing out free medicine packs including Ivermectin.

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