I say "set in concrete" because scientists of all hues, informed by this tradition, still seek the certainty of 'knowledge' (I use 'scientists' in its broadest sense here). I have no problem with this, as long as it is understood that certainty of understanding the complexities of being will never be achieved by any method
I read a recent book on this with the chap making a very similar (if I understand you correctly) argument relating back to Plato ie not everything was knowable and that chance / luck existed. Without acceptance of this society had issues ie in some societies every death was explainable and this led to accusations of sorcery which led to revenge killings etc. In the modern context it leads to law suits over basically everything, as blame must be apportioned.