Suspended past and present Essendon players may need AFL approval to play NAB Cup

[yeahmate]

Sure. However discrediting someone is a common ploy to convince people that they are not to be trusted (in this case, more likely to have given the banned thymosin).

To me, the key here is the dosage regime. TA1 and thymomodulin have short half lives. They need to be given daily to have an effect. TB4 has a long half life and thus is given weekly (sometimes twice weekly) then monthly. If the players confessed to weekly or twice weekly injections, it couldn't have been TA1 or Thymomodulin. Basic pharmacology.
There is no point boosting the immune system for one day of the week!

Just to clarify AT, is this Roy Masters article wrong on the dosages? He has things reversed from what you are saying. Apologies if this has already been addressed elsewhere.

http://www.theage.com.au/afl/afl-ne...ests-on-injection-regime-20141027-11cgku.html

If ASADA's case though is as per Roy's article then that is describing TA1/Thymomodulin dosages and not TB4 dosages?

 

[Albert Ross]

Just to clarify AT, is this Roy Masters article wrong on the dosages? He has things reversed from what you are saying. Apologies if this has already been addressed elsewhere.

http://www.theage.com.au/afl/afl-ne...ests-on-injection-regime-20141027-11cgku.html

If ASADA's case though is as per Roy's article then that is describing TA1/Thymomodulin dosages and not TB4 dosages?

Yeah Roy made some boo-boos in that one. Understandable, none of us quite have our heads around this dossage stuff (well AT does because he is some sort or dealer or something )

The charge sheet is ....

(a) one AOD-9604 injection per week for the season;
(b) one Thymosin injection once a week for six weeks and then one injection per
month;
(c) two Colostrum daily in each training week and two colostrum post-game. The
dose may vary according to training needs; and
(d) one Tribulus forte daily in each training week and one Tribulus prior to the game.
The dose may vary according to training needs.

 

[yeahmate]

Yeah Roy made some boo-boos in that one. Understandable, none of us quite have our heads around this dossage stuff (well AT does because he is some sort or dealer or something )

The charge sheet is ....

(a) one AOD-9604 injection per week for the season;
(b) one Thymosin injection once a week for six weeks and then one injection per
month;
(c) two Colostrum daily in each training week and two colostrum post-game. The
dose may vary according to training needs; and
(d) one Tribulus forte daily in each training week and one Tribulus prior to the game.
The dose may vary according to training needs.

thanks, sounds like he either got things mixed up or his "sports scientist" sources were messing with him

 

[Ancient Tiger]

Just to clarify AT, is this Roy Masters article wrong on the dosages? He has things reversed from what you are saying. Apologies if this has already been addressed elsewhere.

http://www.theage.com.au/afl/afl-ne...ests-on-injection-regime-20141027-11cgku.html

If ASADA's case though is as per Roy's article then that is describing TA1/Thymomodulin dosages and not TB4 dosages?

Thymomodulin dosage (injected, not oral): The dosage needs to be determined on an individual basis depending on the health of the patient. The following dosage is recommended: 10-20 mg/day for 30 days followed by 20-50 mg/week. Continued administration, the dosage, the duration of the treatment depend on the therapeutic effect and the immunological results.

Thymosin alpha 1 dosage: 1.6 mg (900 micrograms/m2) should be administered subcutaneously twice a week. This drug has never been used in any other setting except for severe disease states......

Thymosin beta 4 dosage: (Half life dependent on dosage)
TB500 is distributed as a lyophilized powder that should be kept out of the light (sound familiar) and in a cool dry place. Reconstitution is done with bacteriostatic water or sodium chloride meant for injection. Doses range from 2-2.5mg twice weekly for 4-6 weeks (some user have reported success in dosing higher up to 8mg a week but how much more effective this is yet to be seen) . Beyond that, one to two monthly injections of 2-2.5mg of TB500 can be further utilized to maintain rapid recovery and flexibility in strained areas.

So if using higher doses of TB4, you would go to weekly injections (again sounds familiar).

 

[yeahmate]

Thymomodulin dosage (injected, not oral): The dosage needs to be determined on an individual basis depending on the health of the patient. The following dosage is recommended: 10-20 mg/day for 30 days followed by 20-50 mg/week. Continued administration, the dosage, the duration of the treatment depend on the therapeutic effect and the immunological results.

Thymosin alpha 1 dosage: 1.6 mg (900 micrograms/m2) should be administered subcutaneously twice a week. This drug has never been used in any other setting except for severe disease states......

Thymosin beta 4 dosage: (Half life dependent on dosage)
TB500 is distributed as a lyophilized powder that should be kept out of the light (sound familiar) and in a cool dry place. Reconstitution is done with bacteriostatic water or sodium chloride meant for injection. Doses range from 2-2.5mg twice weekly for 4-6 weeks (some user have reported success in dosing higher up to 8mg a week but how much more effective this is yet to be seen) . Beyond that, one to two monthly injections of 2-2.5mg of TB500 can be further utilized to maintain rapid recovery and flexibility in strained areas.

So if using higher doses of TB4, you would go to weekly injections (again sounds familiar).

This kind of explains why the defence has jumped back to TA1 from Thymomodulin then. Sounds like Thymomodulin can be ruled out on medical evidence on the basis of dosages and frequency whereas TA1 could still be an arguable fit.

 

[Ancient Tiger]

This kind of explains why the defence has jumped back to TA1 from Thymomodulin then. Sounds like Thymomodulin can be ruled out on medical evidence on the basis of dosages and frequency whereas TA1 could still be an arguable fit.

Except the side effect profile would preclude its use IMHO. Although safe to give in disease states, if you give healthy men TA1 and they get polyarthralgia (multiple painful joints) it would be a disaster even if is uncommon.

 

[interestedoz1]

This kind of explains why the defence has jumped back to TA1 from Thymomodulin then. Sounds like Thymomodulin can be ruled out on medical evidence on the basis of dosages and frequency whereas TA1 could still be an arguable fit.

And if TA1 is truly virtually impossible to get, you can see how the case could be made TB4 based on elimination of options