This is my thought also, if we take Ant man & the wasp, Janet states there's a time vortex and not to get stuck before Scott goes into the quantum realm and the three of them get dusted, and that movie focused heavily on Ghost phasing in and out of time so there's precedent somewhat. And since this trailer was rather heavy on what came before, and remembering past instances may prove a part.
Also not sure if teasing, but BW goes through about 4 hairstyle changes in the trailer, so either there's a lot of reflection in the trailer, or some of it bleeds as a sort of hint on time being important, especially so since in IW, Strange is the one that had the time stone and set the course to begin with.
I don’t profess to be a knowledgeable buff, however a few predictions on my part. I think we’d be looking at Infinity War type money for this ($2b gross).
Domestically in the US, I don’t see it surpassing Black Panther which ended up with $700m+ alone. Phenomenal numbers, reflecting a cultural event there.
So many African American would have seen it who otherwise might be casual/impartial superhero fans.
Infinity War notched up ~$630m in the US which is still enourmous numbers.
Internationally China (and the Asian market) remain a goldmine, Aquaman alone generated $250m from China. The demand is certainly there and I think it’s a decent chance to match IW as fastest to $1b of all time (which was 11 days from memory, beating The Force Awakens).
I think Avatar and Titanic have the top two sown up for life - very hard to get singular "event" type movies like that anymore. The Force Awakens and Infinity War as the next two probably went closest to capturing that sort of feeling.