LA: Venice, Echo Park/Silver lake area, Sunset Strip. If stand up comedy is your thing then you absolutely have to go to the comedy store. Go to a late show in the original room and be amazed at who turns upAlright, recommendations for LA, Detroit, Chicago, Indianapolis, Milwaukee, Washington DC, Philly and NY thanks fellas. Off in a couple weeks, can't wait.
Chicago: Logan square/Wicker park, Milwaukee Ave is great for a brewery/bar crawl
NY: Don't be afraid to spend some decent time in Brooklyn. Williamsburg, prospect park are and bushwick are sick. East village and west village/greenwich for all you good restaurants/bars. Walk the high line from west village to hudson yards then go check out the edge nearby