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Would that be a material enough change to necessitate a new batch of stage 2 and 3 trials? That would be a huge disincentive.
Yeah, at this point I wouldn't know what to say about how they'd do trials. Rulebook seems to have gone out the window quite a while ago here on a lot of how these vaccines are being handled because the situation itself is ever evolving (and of course incredibly urgent). Pfizer being given to kids 12 and up here now, talk of Moderna doing that next, and okays being given to mix and match mRNA and viral vector vaccines between doses if necessary. Our last batches of AZ here expired at the end of May, but the official word now from the top docs advising is "yeah, use 'em anyway. It's fine." And I'm sure it is. We all know expiry dates aren't absolutes.
I kind of love seeing how fluid the scientific decision making processes have become throughout all this though. It's been refreshing to hear these voices tasked with what used to be such a fear-based rigid do-not-deviate-from-protocol approach finally just shrug and say "yeah, we can do that, it'll be fine."