The 150 is up for the Sbagman

[sbagman]

Yup, 50 days of my scholarship left, and 150 pages of the thesis done.

On the home stretch now....

 

[Fred]

Could you explain - in simple terms - what it's about?

 

[The Hitman]

Told ya you would get there Rob. Keep going, and I'm sure you'll get the rewards you've been working hard for.

Fred, don't ask. From memory it's pretty complicated stuff?

The Hitman

 

[Santos L Helper]

Good on ya Sbaggie. The finish post is within sight now and so are the benefits that go with it, you know........all the beautiful ladies, sports cars etc., well at least that's what I think comes with a PhD.

 

[lioness]

Nice work sbagman!!!!! Good luck with it.

 

[joshhem]

OH YEAH!!! Almost time to leave that stinking uni hey! How good that would be. Stay focussed

 

[Blues_Girl]

Well Done Rob

See I told you it'll all be over soon!

Maybe one day you'll listen to me....

 

[hawkfan5]

Well done on your great name ROB!

Cheers.

 

[sbagman]

Originally posted by Fred
Could you explain - in simple terms - what it's about?

How's this?

Doctor of Philosophy (ongoing)
The University of Queensland
Institute for Molecular Bioscience

Project under the supervision of Associate Prof. David Fairlie:
"Development of Potent, Cyclic C5a Agonists and Antagonists"

Chapter One is a review of G protein-coupled receptors and how they have been targeted in drug design.

Chapter Two reports the synthesis of a number of cyclic peptides which act as antagonists of the C5a receptor. The resulting SAR is used in generation of an antagonist pharmacophore using molecular modeling.

Chapter Three reports the investigation of the requirements for agonism of the C5a receptor through synthesis of thirty linear and cyclic peptides. An NMR structure of a linear agonist is also reported.

Chapter Four is a homology modeling study of the C5a receptor and includes docking studies of NMR structures of ligands of the C5a receptor.

Chapter Five reports homology modeling studies of metabotropic
glutamate receptors, conducted over eight months under the supervision of Professor Roberto Pellicciari at the University of Perugia, Italy.

 

[Fred]

Great - now it's clear. Just wanted some advance warning so when the Uni sends it to me for review I'll be prepared.

 

[PC28]

sbagman -

Is this regarding Neuroinflamination of Alzheimers, and the brain, blood plasma, etc??

Or have i read this totally wrong?

 

[sbagman]

Originally posted by PC28
sbagman -

Is this regarding Neuroinflamination of Alzheimers, and the brain, blood plasma, etc??

Or have i read this totally wrong?

Well C5a is overexpressed in a whole host of diseases, including Alzheimer's, although the link is quite tenuous. Don't get me wrong though... I'm not a biologist. I'm more interested in developing strategies to target these things when it comes to design of drugs. C5a of more use in things like arthritis, where we have devloped a few working models in rats. But I'm not overly interested in that kinda stuff.

 

[PC28]

Originally posted by sbagman


Well C5a is overexpressed in a whole host of diseases, including Alzheimer's, although the link is quite tenuous. Don't get me wrong though... I'm not a biologist. I'm more interested in developing strategies to target these things when it comes to design of drugs. C5a of more use in things like arthritis, where we have devloped a few working models in rats. But I'm not overly interested in that kinda stuff.

Microvascular strategies?

I know they thought C5a receptor might help in the reduction of neutrophils, and from what i knew there were studies into the effect on Alzheimers.

I don't really know about the arhritis connection, although from what i've read, and what you've said, this seems to be the more focused area of its study...

All over my head though

Good luck anyway

 

[Santos L Helper]

what?