I played the whole first season with 9 minute quarters, just to build up skill points (and learn the game as I went). The second season I'm just playing key games, and the simulation is good enough to not make me regret it too much.
I have plays turned off as well - it gives so much more freedom. Otherwise it feels quite formulaic and tedious. It'd be a lot better if my side (Knicks) didn't turn over all the other starters every season...
I did the reverse in both 2K11, played key games in my first season (did well enough to raise my stats by quite a bit) and finished the build up in the second season by playing EVERY game.
In 2K12 i made sure to play every game, i did skip to playing every key game late in the season. But this was to get to the play offs faster. Didn't really affect my place in the standings as i was battling with Miami for the top spot..... while i had second well and truly sewn up.





. Sadly i didn't follow it up with a decent game (finished with 12 points, 3 assists etc) - i kept on being subbed off after a foul, and wouldn't get put back on until the start of the next quarter.