News Coronavirus Thread

[Snake_Baker]

 

[Hojuman]

Margaret Court’s Victory Life Church in Perth believes their congregants will not contract the coronavirus because they are protected by “ the blood of Jesus "


Ok Margaret.........

 

[Gasometer]

...........of course it's about the lack of medical expertise or any relevance whatsoever to the issue.

FFS, leave Katamatite every once in a while.

I have been self isolating for years

Ahead of the rest of you all fools

Anyway so wats the Sustainability Expert know about Coronavirus?

(There is always one Panellist locked in weeks ahead. Courtney is it this week.)

 

[Snake_Baker]

I have been self isolating for years

I can't see you having any difficulties in achieving this feat.

 

[Gasometer]

Don still in donial

 

[Gasometer]

I can't see you having any difficulties in achieving this feat.

Where have you been the past fortnight?

 

[Snake_Baker]

 

[Gasometer]

....this Live rambling show is making me

 

[Gasometer]

Here we go...Election mode

 

[Snake_Baker]

The binding site interactions have been identified.

Researchers in China report structure of the novel coronavirus bound to its human target

The structure shows the first steps of SARS-CoV-2 infection, and could help in drug discovery

by Megha Satyanarayana March 6, 2020

In another step toward developing treatments and vaccines against the novel coronavirus, SARS-CoV-2, a team of researchers in China have reported the crystal structure of a part of the virus bound to its target on human cells (Science, 2020. DOI: 10.1126/science.abb2762.

The snapshot of this interaction, captured through cryogenic electron microscopy by Qiang Zhou of the Westlake Institute for Advanced Study and colleagues, reveals some of the chemistry behind how the coronavirus hijacks angiotensin converting enzyme (ACE2), an enzyme involved in blood pressure regulation. The researchers think that the structure could lead to the development of antibodies that block this interaction.

The new cryo-EM structure comes hot on the heels of another revealed in February that showed the full viral spike protein, which is the part of the virus that binds ACE2 (Science, 2020. DOI: 10.1126/science.abb2507). Jason McLellan, the University of Texas at Austin researcher who led the team behind the spike protein structure, says that Zhou’s team’s work will help scientists better understand how coronaviruses have evolved to use this critical enzyme to get into human cells. He also agrees that the interaction captured in the structure could inspire the development of neutralizing antibodies. McLellan’s work with the coronavirus spike protein is being developed into a vaccine.

ACE2 is the first in a string of enzymes that convert the hormone angiotensin into its active form. When cleaved by enzymes, angiotensin makes blood vessels contract. The SARS-CoV-2 spike protein has two key elements involved in infecting human cells. A string of amino acids in the S1 subunit directly binds to the protein-cleaving part of ACE2 called the peptidase domain. The S2 subunit of the spike protein helps the virus fuse to the human cell. The new structure shows the first of these two events.

“You have attachment, and entry. Blocking either function can prevent entry,” McLellan says, describing how treatments could be designed to stop SARS-CoV-2. “Ideally, you want antibodies that can target both functions.”

The ACE2 protein has a section that winds through the cell membrane, and that section has been difficult to crystallize. To overcome this, Zhou and his team paired it with another protein, an amino acid transporter, that it interacts with in cells. Once the researchers crystallized the ACE2 complex, they added a portion of the spike protein’s S1 subunit called the receptor binding domain. It’s not clear if that amino acid transporter plays any role in coronavirus infection.

The scientists found that the protein-cleaving part of ACE2 binds the spike through polar interactions formed from a bridge-like structure on the enzyme. Both ends of the receptor binding domain stick to ACE2 through hydrogen bonding and van der Waals forces, and in the middle, Zhou describes several amino acids that interact with an asparagine and histidine in ACE2 that may be required for the spike protein-ACE2 interaction to occur.

McLellan says that SARS-CoV-2 binds ACE2 more strongly than does the virus that caused the severe acute respiratory syndrome outbreak in 2003. Zhou’s research shows the subtle amino acid changes that create salt bridges and improve van der Waals interactions that might underlie this stronger interaction, he says.

Efforts to repurpose ACE2 inhibitors to block coronavirus infection have not been successful in the past, and McLellan says that given what has been revealed in this structure, it would be hard to develop a small molecule inhibitor that could squeeze between the virus and ACE2. Neutralizing antibodies, he says, might be a better bet.

Chemical & Engineering News
ISSN 0009-2347
Copyright © 2020 American Chemical Society

 

[Snake_Baker]

Now to identify the antigen profile of these "spike proteins" in order to facilitate a vaccine, and then this ****er joins the dinosaurs.

 

[Reagan Smash]

The English Premier League has been suspended.

Wouldn't surprise me at all if Gillon follows suit

 

[Hojuman]

The English Premier League has been suspended.

Wouldn't surprise me at all if Gillon follows suit

Would make sense to see what happens over the next 4 - 5 weeks and then you play everyone once if possible and go from there.

 

[Gasometer]

Would make sense to see what happens over the next 4 - 5 weeks and then you play everyone once if possible and go from there.

It’s also a the ancillary businesses associated with AFL that suffer

 

[Boomerfan99]

More insulting of your intelligence from the ABC's version of The Jerry Springer Show.

View attachment 839222

Yes, it's of vital importance that we get diversity expertise (Courtney Act) about Covid19.

Good old ABC.

 

[Snake_Baker]

Good old ABC.

They should close it down and give the money to the science community.

The real science community, not the political activist science community.

 

[Val Keating]

LOL President Bolsonaro tests positive for the illness. He said it was fake news 3 days ago.

 

[GarnerSmash]

Would make sense to see what happens over the next 4 - 5 weeks and then you play everyone once if possible and go from there.

Generally speaking, once the number of cases in a country has hit the 200 mark, infection rates go nutso. Yesterday we were on 156. Today its 199.

Buckle up folks.

 

[giantroo]

China blaming US

Chinese official suggests coronavirus started in United States

Escalating a war of words between Washington and Beijing amid the coronavirus pandemic, a prominent firebrand official in China takes to Twitter to suggest the US Army brought COVID-19 to Wuhan.

www.abc.net.au

 

[Hojuman]

So they are saying on the AFL website that games may be shortened and teams may have to play games in quick succession with top-up players ?

Gil; " North Melbourne will play all their interstate interstate games in 2 weeks:
Sunday - Eagles in Perth
Wednesday - Lions in Brisbane
Saturday - Port in Adelaide
Monday - Sydney in Sydney
Thursday - Freo in Perth
Sunday - Crows in Adelaide

" Collingwod & Richmond meanwhile it has been decided should have all their games at the MCG due to contractual reasons "

 

[Snake_Baker]

 

[Val Keating]

Bang on

 

[Hojuman]

Bit of perspective.

My mum was born in Wilhelmsaven Northern Germany 1934. Lived through WW2 for 6 years from age 5 - 11.

Reckon we might not be that badly off

 

[Only Forwards]

Bit of perspective.

My mum was born in Wilhelmsaven Northern Germany 1934. Lived through WW2 for 6 years from age 5 - 11.

Reckon we might not be that badly off

Her and her family were probably more mentally resilient that a large proportion of society currently.

For decades we've been conditioned that when you're scared and uncertain you buy things.

This consumerism mixed with fear of the uncertain is playing out with people doing absolutely ridiculous things. Whats happened with toilet paper is a superb analog of the fear and self centered nature of our society.

 

[Only Forwards]

Oh and how well are woolies and coles doing out of this. So many empty shelves.

Might need to buys some of their shares especially if they're dipping currently because their end of year profit is going to be brilliant.